What we study, and why it matters.

— SCIENCE

Our research program spans molecular genetics, epigenomics, and developmental biology — unified by a single central question: what enables a heart to fully regenerate?

—— RESEARCH AREAS
Featured
Mechanisms for controlling gene expression during zebrafish heart regeneration

Zebrafish can fully regenerate cardiac muscle after ventricular resection or cryoinjury — a capacity largely absent in adult mammals. We use these injury models to map the temporal and spatial dynamics of cardiac repair at single-cell resolution, tracking cardiomyocyte proliferation, epicardial activation, and inflammation resolution across the regenerative timeline.

Read more →
Selective mRNA translation during regeneration

Zebrafish can fully regenerate cardiac muscle after ventricular resection or cryoinjury — a capacity largely absent in adult mammals. We use these injury models to map the temporal and spatial dynamics of cardiac repair at single-cell resolution, tracking cardiomyocyte proliferation, epicardial activation, and inflammation resolution across the regenerative timeline.

Read more → 
— MODEL ORGANISM

Danio rerio

The zebrafish is an ideal model for cardiac regeneration research. It shares key developmental and genomic features with mammals while retaining the remarkable ability to fully repair injured heart tissue in adulthood.

High conservation of cardiac gene regulatory networks and genetic tractability make zebrafish uniquely suited to mechanistic regeneration studies.